AI4SC

AI FOR SINGLE-CELL SCIENCE

Decode every cell.
Discover living systems.

Connecting artificial intelligence and single-cell science to move from cellular atlases toward biological mechanisms.

Explore our research Open scTHREAD
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ABOUT AI4SC

A new way to understand
cellular complexity

AI4SC is a research institute and open community at the frontier of artificial intelligence and single-cell science.

We focus on consequential scientific questions: learning transferable biology from sparse, heterogeneous data; grounding predictions in testable mechanisms; and turning methods into open resources that researchers can use.

Learn more about AI4SC
A digital biology landscape extending from an individual cell through cellular networks to tissue
Understanding life across scalesCELL · TISSUE · SYSTEM
CellObserve
TissueConnect
SystemUnderstand
DiscoveryTranslate

RESEARCH DIRECTIONS

Computational innovation
for biological questions

Four connected directions span the path from representation and integration to intervention and transcript-level mechanisms.

01
A single-cell foundation model concept composed of diverse cell forms and digital connections

Single-cell foundation models

Representation learning, foundation models, interpretability and reliability for cellular states and biological contexts.

FOUNDATION MODELS
02
Layered cells and multimodal information converging within spatial tissue

Multimodal & spatial intelligence

Joint understanding of transcriptomic, epigenomic, proteomic and spatial information within tissues.

MULTIMODAL & SPATIAL
03
A localized perturbation branching into cellular response paths

Perturbation & causal discovery

Learning perturbation response and cell-state transitions to connect prediction, mechanism and intervention.

PERTURBATION & CAUSALITY
04
Multiple full-length transcript and splicing paths extending between cells

Long-read & isoform intelligence

Resolving splicing, isoforms and regulation to extend the reach and resolution of single-cell transcriptomics.

LONG-READ & ISOFORMS
View the full research agenda

FEATURED PLATFORM

Turning methods into
usable scientific resources

AI4SC builds open, traceable and reusable research infrastructure alongside new computational methods.

Open scTHREAD Our platform principles
AI4SC / PLATFORM 01LIVE ↗
scTHREADSingle-cell long-read transcriptome resource
  • Browse
  • Analyze
  • Predict
  • Tools

OPEN COMMUNITY

Where disciplines meet
around the same question

We connect AI, computational biology, single-cell technology, discovery science and translational medicine to shorten the distance from algorithms to insight.

How to participate
Artificial IntelligenceSingle-cell OmicsComputational BiologyTranslational Science
04

COLLABORATE
WITH AI4SC

BUILD WITH US

Define what comes next for
AI × single-cell science

We welcome long-term collaborations with computational, experimental, clinical and industry partners around real scientific questions.

Talent and participation